|Maria Celia Jamur
Tel.: (16) 3315-3142
Study of the recruitment and migration of mast cell precursors and immature and mature mast cells by different in vitro and in vivo models.
Recent studies carried out in our laboratory have identified the committed precursor for the mast cell lineage and a mast cell population in the maturation phase, in the bone marrow of rats and mice. Our ongoing studies aim to understand the mechanisms that induce migration of these cells from the bone marrow to peripheral sites during recruitment, a process similar to inflammation and allergy. In vivo and in vitro studies are performed by employing specific markers for these two populations, associated with experimental models, aiming at mast cell recruitment to peripheral tissues. The pathway followed by mast cell precursors and mast cells undergoing maturation to the various organs is being investigated after their isolation, targeting, and reintroduction into animals. Molecules involved in mast cell proliferation, migration, and adhesion are also analyzed using RBL-2H3 mast cell lineage and mutant lineages, as well as knockout animals.