Luis Lamberti Pinto da Silva
Ms 5
Tel.: (16) 3315-3144
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General Outline 

Our laboratory studies the cell and molecular mechanisms that control trafficking of transmembrane proteins within the secretory pathway and how these processes are hijacked by viruses. 

Research Interests

The work in the laboratory has currently three foci: 1) The molecular mechanisms by which HIV-1 Nef and Vpu proteins modify intracellular protein trafficking pathways to induce changes in the intracellular fate of host restriction factors. 2) The molecular mechanisms involved in targeting of HIV-1 gp41/gp120 envelope proteins within the host secretory pathway and how this influences viral production and infectivity. 3) The cell and molecular mechanisms involved in protein transport and assembly of Bunyaviruses that cause human diseases.

Selected Publications (from the last five years)

Dias MVS, Costa CS, daSilva LLP.The Ambiguous Roles of Extracellular Vesicles in HIV Replication and Pathogenesis. Front Microbiol. 2018 Oct 10;9:2411. doi: 10.3389/fmicb.2018.02411.

daSilva LLP, Mardones GA. HIV/SIV-Nef: Pas de trois Choreographies to Evade Immunity.Trends Microbiol. 2018 Nov;26(11):889-891. doi:10.1016/j.tim.2018.09.003. 

Barbosa NS, Mendonça LR, Dias MVS, Pontelli MC, da Silva EZM, Criado MF, da Silva-Januário ME, Schindler M, Jamur MC, Oliver C, Arruda E, daSilva LLP. ESCRT machinery components are required for Orthobunyavirus particle production in Golgi compartments. PLoS Pathog. 2018 May 3;14(5):e1007047. doi: 10.1371/journal.ppat.1007047.

González AE, Muñoz VC, Cavieres VA, Bustamante HA, Cornejo VH, Januário YC, González I, Hetz C, daSilva LL, Rojas-Fernández A, Hay RT, Mardones GA, Burgos PV.Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway.FASEB J. 2017 Jun;31(6):2446-2459. doi: 10.1096/fj.201600713R.

Tavares LA, da Silva EM, da Silva-Januário ME, Januário YC, de Cavalho JV, Czernisz ÉS, Mardones GA, daSilva LL. CD4 downregulation by the HIV-1 protein Nef reveals distinct roles for the γ1 and γ2 subunits of the AP-1 complex in protein trafficking. J Cell Sci. 2017 Jan 15;130(2):429-443. doi: 10.1242/jcs.192104. DaSilva LL, Wall MJ, P de Almeida L, Wauters SC, Januário YC, Müller J, Corrêa SA.

Activity-Regulated Cytoskeleton-Associated Protein Controls AMPAR Endocytosis through a Direct Interaction with Clathrin-Adaptor Protein 2. eNeuro. 2016 May 24;3(3). pii: ENEURO.0144-15.2016. doi: 10.1523/ENEURO.0144-15.2016.

Pereira EA, daSilva LL.HIV-1 Nef: Taking Control of Protein Trafficking. Traffic. 2016 Sep;17(9):976-96. doi: 10.1111/tra.12412.

de Carvalho JV, de Castro RO, da Silva EZ, Silveira PP, da Silva-Januário ME, Arruda E, Jamur MC, Oliver C, Aguiar RS, daSilva LL. Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection. PLoS One. 2014 Nov 25;9(11):e113691. doi: 10.1371/journal.pone.0113691.

Amorim NA, da Silva EM, de Castro RO, da Silva-Januário ME, Mendonça LM, Bonifacino JS, da Costa LJ, daSilva LL. Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor. J Biol Chem. 2014 Oct 3;289(40):27744-56. doi: 10.1074/jbc.M114.560193.


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