Advisor
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Thiago Mattar Cunha Tel.: (16) 3315-3595 Email: thicunha@usp.br» |
General Outline
Chronic pain is an important clinical condition since there are no effective treatments. Also, the drugs available on the market have a number of side effects that limit their use. In this sense, the study of the cellular and molecular mechanisms involved in the development of chronic pain can certainly point to new targets for the development of more effective drugs with fewer side effects. In this sense, our research group has been developing projects that involve the characterization of these mechanisms through approaches in vivo and in vitro with pharmacological and genetic/molecular tools and the most modern methodologies RNA-scope, single-cell RNA-seq, CRISPR/CAS9, electrophysiology, among others.
Research Areas
1. Neuro-immune-glial interactions in the development of pathological pain
2. Role of cell metabolism in the neuroinflammation
3. Molecular basis of peripheral analgesia
Selected Publications (186)
1. Silva MC, Davoli-Ferreira M, Medina TS, Sesti-Costa R, Silva GK, Lopes CD, Cardozo LE, Gava FN, Lyroni K, Dias FC, Frade AF, Baron M, Nakaya HI, Figueiredo F, Alves-Filho JC, Cunha FQ, Tsatsanis C, Chevillard C, Cunha-Neto E, Hirsch E, Silva JS, Cunha TM*. Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis. Nat Commun. 2018; 9(1):1513. * Corresponding author
2. Silva JR, Lopes AH, Talbot J, Cecilio NT, Rossato MF, Silva RL, Souza GR, Silva CR, Lucas G, Fonseca BA, Arruda E, Alves-Filho JC, Cunha FQ, Cunha TM*. Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia. J Neurosci. 2017 Jul 5;37(27):6408-6422. * Corresponding author
3. Cunha TM*, Moriconi A*, Souza GR, Lopes AH, Cunha FQ, Carneiro VL, Pinto LG, Brandolini L, Aramini A, Bizzarri C, Bianchini G, Beccari AR, Fanton M, Bruno A, Costantino G, Bertini R, Galliera E, Locati M, Ferreira SH, Teixeira MM, Allegretti M. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proc Natl Acad Sci USA. 2014 Nov 25;111(47):16937-42. * Contributed equally
4. Souza GR, Talbot J, Lotufo CM, Cunha FQ, Cunha TM*, Ferreira SH*. Fractalkine mediates inflammatory pain through activation of satellite glial cells. Proc Natl Acad Sci USA. 2013 Jul 2;110(27):11193-8. doi: 10.1073/pnas.1307445110. * Corresponding authors
5. Cunha TM*, Roman-Campos D, Lotufo CM, Duarte HL, Funez MI, Verri WA JR, Souza GR, Domingues AC, Sachs D, Chiavegatto S, Teixeira MM, Hothersall JS, Cruz JS, Cunha FQ, Ferreira SH. Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/NNOS/NO/KATP signaling pathway. Proc Natl Acad Sci USA 2010, 107(9):4442-7. * Corresponding author
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» Scholar
Opportunities
Students and researches from all levels are welcome to join the group. Master and PhD candidates should consider the Cell and Molecular Biology program from the Ribeirão Preto Medical School.
Center for Research in Inflammatory Diseases (CRID). Department of Pharmacology
Av. Bandeirantes 3900, FFCLRP-USP, Departmento de Biologia, Bloco 15. Bairro Monte Alegre, Riberão Preto-SP, Brazil.
Tel: +55-16-3315-0199.